Liverpool's new £45m signing Diogo Jota grabbed a home debut goal as the champions demonstrated their determination to retain an iron grip on their Premier League crown by coming from behind to record an impressive victory against Arsenal at Anfield.
Newcastle rescued an injury-time point against Tottenham Hotspur from the penalty spot entirely against the run of play after another controversial handball decision.
Guardiola suffered his worst home defeat as City boss as Jamie Vardy scored a hat-trick as Leicester City go top of the Premier League.
A dramatic injury-time penalty, given by VAR after the whistle had been blown, gave Manchester United victory at Brighton and their first three points of the season in a stunning game at Amex Stadium.
Tammy Abraham scored a stoppage-time equaliser to complete an incredible comeback and rescue a point for Chelsea at West Bromwich Albion after they had trailed 3-0 at half-time.
Manchester City held off a second-half Wolves fightback to begin their quest to regain the Premier League title with a win at Molineux.
Son Heung-min said it was "incredible" to score four goals as Tottenham secured their first Premier League win of the season by coming from behind to thrash Southampton.
Neal Maupay scored twice as Brighton cruised to a comfortable Premier League victory over an under par Newcastle at St James' Park.
Liverpool delivered a powerful statement of intent about their desire to retain the Premier League title with a comfortable dismissal of Chelsea at Stamford Bridge on another nightmare day for keeper Kepa Arrizabalaga.
Wilfried Zaha scored twice against his former club as Crystal Palace condemned Manchester United to a miserable start to their Premier League campaign with victory at Old Trafford.
Arsenal boss Mikel Arteta praised his side's mental strength after Eddie Nketiah's late winner maintained their 100% start to the season against West Ham.
An expensively renewed Chelsea began their campaign with victory at Brighton after Manager Frank Lampard says they "have to have intentions to be up there" with champions Liverpool
Dominic Calvert-Lewin's brilliant header ensured new-look Everton made a flying start to the Premier League season with victory at Tottenham.
Debutants Gabriel and Willian impressed as Arsenal blew away promoted Fulham in the opening game of the Premier League season.
Due to Manchester United's late involvement in the Europa League last season, their season opener with Burnley has been postponed to allow their players a little extra time to prepare for the season
Likewise to their cross-Manchester neighbours, City's progression through the Champion's League last season, causes their first game of the Premier League season with Aston Villa to be postponed
The Champions of England's top 2 divisons go head-to-head in their first game of the season. It did not disappoint. Both teams adopted a gung-ho approach, of which the Liverpool game out on top.
New Signings Callum Wilson and Jeff Hendrick both scored as Newcastle made a winning start to the 2020-21 Premier League season against an lacklustre West Ham.